Number of reported cases of tuberculosis (DOTS) (number)
| 2000 | 2005 | 2010 | 2011 | 2012 | 2013 | 2014 | 2015 | 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | 2023 |
| Botswana | 9,292 | 10,058 | 7,013 | 6,603 | 6,848 | 6,834 | 6,019 | 4,972 | 5,460 | 5,274 | 4,654 | 3,089 | 2,484 | 2,350 | 2,624 | 1,753 |
| Lesotho | 9,746 | 10,802 | 11,674 | 11,561 | 10,776 | 9,555 | 8,840 | 7,594 | 7,352 | 7,117 | 7,111 | 7,059 | 4,565 | 4,490 | 5,599 | 6,495 |
| Eswatini | 5,877 | 8,705 | 10,101 | 8,337 | 7,165 | 6,641 | 5,583 | 4,266 | 3,567 | 3,367 | 2,987 | 2,876 | 2,143 | 1,934 | 2,374 | 2,297 |
| South Africa | 151,239 | 270,178 | 354,786 | 362,453 | 323,664 | 312,380 | 306,166 | 287,224 | 237,045 | 243,297 | 227,999 | 209,545 | 191,074 | 172,194 | 214,295 | 211,810 |